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Abstract ID: 24-168
Correlation of quality of life and self-administrated DED questionnaires in meibomian gland dysfunction
Kelvin Chong
Purpose
To investigate the relationship between generic versus dry eye disease(DED) quality of life (QOL) questionnaires in subjects with mild-to-moderate meibomian gland dysfunction (MGD) before enrolling in a randomized clinical trial (ClinicalTrials.gov ID NCT05577910).
Methods
The generic 36-Item Short Form Surveys(SF-36) consisting of Physical Component Summary(PCS) and Mental Component Summary(MCS), the 5-Item Dry Eye Questionnaire(DEQ-5), Standard Patient Evaluation of Eye Dryness Questionnaire(SPEED), Ocular Surface Disease Index(OSDI), and Symptom Assessment In Dry Eye(SANDE) were self-administered by patients at baseline. Multiple linear regression (MLR) models were used to assess the correlation between SF-36 and four DED questionnaires using SPSS V.29.
Results
47 subjects (40 females, 85%), aged 59.79 ±9.01 were recruited. Mean(SD) of PCS and MCS were 301.8(60.9) and 278.7(57.1). Significant correlation was found between PCS and OSDI (Unstandardized B= -1.62, p=0.002) and between MCS and OSDI (Unstandardized B=-1.76, p<0.01). No correlation was found between the other three DED questionnaires with PCS or MCS.
Conclusion
OSDI was found, for the first time, to correlate with generic QOL questionnaires in MGD patients to generalize its impact to other eye or medical conditions. The other three commonly used DED questionnaires do not correlate with the limitations of QoL as measured by SF-36 in mild-moderate MGD. Future studies in patients with moderate-to-severe MGD and patients without other medical or mental comorbidities will be necessary.
Additional Authors
Jeffrey Chun Fung Lam – Department of Ophthalmology & Visual Sciences, the Chinese University of Hong Kong
Zhichao Hu – Department of Ophthalmology & Visual Sciences, the Chinese University of Hong Kong
Stella Weng Chi Sio – Department of Ophthalmology & Visual Sciences, the Chinese University of Hong Kong
Nicole Tsz Yan Wong – Department of Ophthalmology & Visual Sciences, the Chinese University of Hong Kong