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Abstract ID: 24-115
Ocular Surface Damage Characteristics of Thyroid-Associated Ophthalmopathy Patients with Different Activities
Rong Lu
Purpose
To evaluate the association of thyroid-associated ophthalmopathy (TAO) with ocular surface changes and investigate the relation of ocular surface parameters with different disease activity.
Methods
Patients diagnosed as TAO with different clinical activity scores (CAS) were recruited. All subjects underwent a complete ophthalmic examination and non-contact ocular surface analyzer. Ocular surface parameters including the Tear meniscus height (TMH)、non-invasive breakup time (NIBUT) 、Conjunctival Redness、Tear Film Lipid Layer Grade、Meiboscore and Fluorescein staining were measured. Areas under the receiver operating characteristic curves (AUROCs) were applied to evaluate the diagnostic accuracy of microvascular alterations for active TAO.
Results
A total of 100 eyes were included in the study, with 49 eyes in the active TAO group and 51 eyes in the inactive TAO group. Dry eye symptoms were more severe in the active group compared to the inactive group. The median Ocular Surface Disease Index (OSDI) score was significantly higher in the active group compared to the inactive group. Additionally, the active group had a lower TMH、NIBUT (P < 0.05). Notably, conjunctival redness, particularly in the temporal and nasal areas, and temporal canthus, were significantly higher in the active group. The Meibum quality score 、fluorescein staining score and the meiboscore of the upper eyelid were significantly higher in the active group (P < 0.05). The active TAO group predominantly exhibited mixed dry eye (61.20%), whereas the inactive TAO group had a higher prevalence of evaporative dry eye/MGD type (47.10%). Meanwhile, the temporal conjunctiva redness was positively correlated with CAS (r=0.805).
Conclusion
TAO patients experience more severe dry eye symptoms and ocular surface changes. Notably, temporal conjunctiva redness exhibited a strong positive correlation with CAS and proved to be a reliable indicator for distinguishing the active stage of TAO. Our findings contribute valuable insights into the ocular manifestations of TAO and may aid in the development of targeted interventions for improved patient care.
Additional Authors
Yujun Ma – State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China.
Jinmiao Li – State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China.
Yang Gao – State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China.